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This book provides a detailed update on our knowledge of dental pulp and regenerative approaches to therapy. It is divided into three parts. The pulp components are first described, covering pulp cells, extracellular matrix, vascularization, and innervation as well as pulp development and aging. The second part is devoted to pulp pathology and includes descriptions of the differences between reactionary and reparative dentin, the genetic alterations leading to dentinogenesis imperfecta and dentin dysplasia, the pulp reaction to dental materials, adverse impacts of bisphenol A, and the effects of fluorosis, dioxin, and other toxic agents. The final part of the book focuses on pulp repair and regeneration. It includes descriptions of various in vitro and in vivo (animal) experimental approaches, definition of the pulp stem cells with special focus on the stem cell niches, discussion of the regeneration of a living pulp, and information on new strategies that induce pulp mineralization. Table of Contents Section 1 Pulp Biology - Pulp Development
—Sasha Dimitrova-Nakov DDS, PhD, Michel Goldberg DDS, PhD - Pulp Anatomy and Characterization of Pulp Cells
—Michel Goldberg DDS, PhD - Pulp Extracellular Matrix
—Arthur Veis PhD, Michel Goldberg DDS, PhD - Strategies for Tracking the Origin and Fate of Odontoblasts and Pulp Cell Progenitors
—Mina Mina DMD, MSD, PhD - Pulp Vascularization and Its Regulation by the Microenvironment
—Imad About PhD - Dental Pulp Innervation
—Kaj Fried DDS, PhD, Jennifer Lynn Gibbs MAS, DDS, PhD - Inflammatory Processes in the Dental Pulp
—Paul R. Cooper PhD, Anthony J. Smith PhD - Pulp Aging: Fibrosis and Calcospherites
—Michel Goldberg DDS, PhD
Section 2 Pulp Pathology - Pulp Inflammation: From the Reversible Pulpitis to Pulp Necrosis During Caries Progression
—Lars Bjørndal DDS, PhD, Domenico Ricucci MD, DDS - Reactionary and Reparative Dentin-Like Structures
—Michel Goldberg DDS, PhD - Genetic Alterations: Heritable Dentin Defects
—Agnès Bloch-Zupan HDR, PhD, DDS - Pulp Reactions to Dental Materials
—Gottfried Schmalz DDS, DMD, PhD - Effects of Bisphenol A on the Dental Pulp
—Michel Goldberg DDS, PhD - Fluoride Effects on the Dentin-Pulp Complex
—Yukiko Nakano DDS, PhD, Pamela Den Besten DDS, MS
Section 3 Pulp Repair and Regeneration - Experimental In Vivo Approaches of Pulp Regeneration
—Misako Nakashima PhD, DDS, Koichiro Iohara DDS, PhD - Pulp Stem Cells: Niches of Stem Cells
—Michel Goldberg DDS, PhD - Regeneration of the Living Pulp
—Tracy L. de Peralta DMD, PhD, MClinEd, Jacques Eduardo Nör DDS, MS, PhD - Scaffolds for Pulp Repair and Regeneration
—Kerstin M. Galler DDS, PhD - Regenerative Endodontics: Regeneration or Repair?
—Stephane Simon DDS, PhD, Michel Goldberg MD, DDS
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