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The results of the present study indicates that the tooth can act as a barrier for medication diffusion and does not block it completely, because not only Ca2+ and OH- can diffuse through dentin and reach the external root surface but other components of the vehicle used can also diffuse and reach the external surface. Each medicament presents different diffusion characteristics, which will be directly related to its interaction with the tooth structure. Thus, more research is needed to determine which components of vehicles permeate the dentin, in what quantity they permeate, and whether these components have any effect on the periodontium. Author Information Sultan Omer Sheriff BDS, MDS is Senior Lecturer Department of Restorative Dentistry, International Medical University, Malaysia.
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