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The current study was performed to prepare a fully natural endodontic irrigant solution from castor oil and papain enzyme, and evaluate its physical, chemical, biological, and clinical requirements. This was done through the FTIR test, surface tension test, pH measurement, Biocompatibility, Antibacterial action of the solution, Microleakage, the effect of solution on the smear layer removal, Pushout shear bond strength test, the effect of storage time 6 months on the antibacterial action, and smear layer removal. Author Information Amer A. Taqa PhD is Professor at Dental Basic Science, College dentistry, Mosul University, Iraq. His PhD is in Dental chemistry. He has published more 100 researches papers in national and international academic journals and authored 22 books. Talal H. Al-Salman BDS, MSc is a Lecturer for the Department of Conservative Dentistry, College of Dentistry, University of Mosul. Nawfal Abdul Malek Abdul Fatah is an Assistant Professor in the Department of Conservative Dentistry, University of Mosul, Iraq.
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