2010-07-28 Regenerative Dentistry: Synthesis Lectures on Tissue Engineering by Kyriacos A. Athanasiou PhD PhMMona K. Marei BDS MScD PhD Paperback
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Regenerative Dentistry: Synthesis Lectures on Tissue Engineering
By Kyriacos A. Athanasiou PhD PhM (Editor) and Mona K. Marei BDS MScD PhD
5.0 out of 5 stars (1 Reviews)
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Publisher:  Morgan And Claypool Publishers
Edition:  1st
Published:  July 28, 2010
Binding:  Paperback
Pages:  178
Product Description:
In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors.

We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry.

Table of Contents:

  1. Introduction to Regenerative Dentistry
  2. Tissue Engineering Alveolar Bone
  3. Tissue Engineering of the Periodontal Tissues
  4. Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry
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5.0 out of 5 stars.  NEW TEETH CAN BE GROWN, November 28, 2014
By Dave (Florida, USA)
Whole teeth can be made to regenerate in socket with cells infused within collagen sponges (page 5): Ikeda "Fully functional bioengineered tooth replacement as an organ replacement therapy". Newer technology uses a aggregation of cells to produce a tooth germ which is capable of developing into a whole tooth. See EP2633870 Rosowski "Method of preparing an artificial tooth primordium in vitro". A stem cell niche is a microenvironment created for morphogen induced morphogenesis. Morphogenesis requires (1) osteoinductive soluble signal (2) an substratum which delivers the signal and acts as a scaffold for new bone formation (3) host cells capable of differentiating into the osteoblastic phenotype (page 86). Stem cells are a small portion of a large harvest and survive longer because they are clonogenic. They are marked and sorted with Florescence (FACS) or Magnetic (MACS) Activated Sorting (page 10). In MACS, an antibody with a magnetic bead is docked on the mesenchymal cells surface receptor. The cells with the beads are trapped in a magnetic field as they are dropped then separated and cultured on a neutrally charged surface (not glass): "Method of enriching for mesenchymal precursor cells" US20120082649. Distraction Osteogenesis is the regeneration of skeletal bone differentiates cells based upon mechanical stimulation between cells. The properly implanted cells can alter the host response causing continual turnover of cells after the transplanted donor cells undergo apoptosis and die (page 39): Tortelli "The development of Tissue-Engineered bone of different origin", Nakajima "Periodental tissue engineering by transplantation of multilayered sheets" Scaffolds have been designed to release naked plasma DNA containing genes encoded with growth factors to transform injected tissue into bioreactors to stimulate the production of teeth, cartilage, blood vessels, etc. Older technology of placing microspheres filled fragile morphogenetic growth factors into scaffolds were too unstable to complete regeneration (page 50). "Stimulating regeneration with naked DNA" US20050197304. The greatest challenge of all is the selection of recombinant morphogens (page 84). Advanced 3D printers have been developed with the capability of spraying any type of cell, gene, growth factor, or material needed to create complex layered sculptures of tissue complete with internal tunnel networks for tissue support and maintenance. These scaffolds will attract cells to colonize the implanted tooth and give it life: "Tooth scaffolds" US20120282573. Dentin is a mineralized, extracellular matrix that forms the skeletal tissue of the tooth (page 112). The 3D printers can create artificial stem cell niches fed by nutrients to culture cells involved in metamorphoses and regeneration: "3D in vitro bi-phasic cartilage-bone construct". Only dental pulp cells posses the ability to differentiate into odontoblast. Odontoblast originate from neural crest cells and their differentiation results from continuous reciprocal interactions between epithelial and mesenchymal components of the developing tooth germ. A functional network of dentin matrix molecules in the basement membrane seems to control odontoblast differentiation (page 117): Ruch JV "Odontoblast differentiation". This book goes into the biochemistry in more detail.

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